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KMID : 0939920090410020104
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대한암학회지
2009 Volume.41 No. 2 p.104 ~ p.107
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Complete Remission in a Patient with Human Herpes Virus-8 Negative Multicentric Castleman Disease Using CHOP Chemotherapy
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Seo Hee-Yeon
Kim Eui-Bae
Kim Jee-Won
Shin Bong-Kyoung
Shin Bong-Kyoung
Kim Seok-Jin
Kim Byung-Soo
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Abstract
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Multicentric Castleman disease (MCD) is a rare lymphoproliferative disorder. Although MCD pathogenesis is unclear, studies have suggested that human herpesvirus 8 (HHV-8) may be associated with the disorder. Recent reports have identified MCD cases without viral infection. A 43-year-old woman presented to our hospital for fever and myalgia of 6 months’ duration. The complete blood count revealed an elevated leukocyte count (15.1103/L) and a decreased hemoglobin level of 10.0 g/dL. The C-reactive protein level was elevated at 276.5 mg/L. Thoracic computed tomography (CT) scans revealed bilateral axillary lymph-adenopathy. There was no evidence of HHV-8, human immunodeficiency virus (HIV), or Mycobacteriuminfection. Histologic evaluation of a lymph node biopsy from the left axilla yielded a diagnosis of MCD. Cyclophosphamide, adriamycin, vincristine, and prednisone (CHOP) were administered for a total of 4 cycles. The patient’s fever and lymphadenopathy resolved after the course of chemotherapy. She has been in complete remission for 24months at this writing. As previously reported, this case report suggests that MCD can develop without viral infection. CHOP chemotherapy may be an effective treatment option for newly diagnosed MCD patients.
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KEYWORD
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Chemotherapy, Human herpes virus 8, Multicentric Castleman disease
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